ChemicalBook CAS DataBase List 2-Bromo-5-methylbenzenamine

2-Bromo-5-methylbenzenamine synthesis

7synthesis methods

Product Name:2-Bromo-5-methylbenzenamine
CAS Number:53078-85-6
Molecular formula:C7H8BrN
Molecular Weight:186.05

5326-34-1 Synthesis

5326-34-1
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53078-85-6
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Yield:53078-85-6 99%

Reaction Conditions:

with formic acid;triethylamine;platinum on carbon at 100; for 12.3333 h;

Steps:

1 Synthesis of 2-bromo-5-methylaniline
Production Example 1 Synthesis of 2-bromo-5-methylaniline 4-Bromo-3-nitrotoluene (60.35 g, 279 mmol), 5% by weight platinum carbon (1.09 g, 0.28 mmol) and triethylamine (112.93 g, 1116 mmol) were stirred under heating at 100° C., to which formic acid (99%) (42.39 g, 921 mmol) was added dropwise over 20 minutes. After stirring for 12 hours, it was brought back to room temperature, and then 100 ml of ethyl acetate and 100 ml of water were added thereto. After stirring well, it was filtered through celite to remove platinum carbon. By further adding 200 ml of ethyl acetate and 100 ml of water, it was extracted, the organic phase was washed with water (300 ml*3 times), and dried on magnesium sulfate. The solvent was evaporated to obtain 2-bromo-5-methylaniline (51.30 g, 276 mmol). The yield was 99%. ¹H-NMR (270 MHz, CDCl₃) δ(ppm): 7.260 (1H, d), 6.583 (1h

References:

Saitoh, Hiroshi;Mizuno, Tsuyoshi;Tsuchiya, Naoki US2003/191325, 2003, A1 Location in patent:Page/Page column 8

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5326-34-1 Synthesis

5326-34-1
249 suppliers
$6.00/5g