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ChemicalBook CAS DataBase List 8-Aminoisoquinoline
23687-27-6

8-Aminoisoquinoline synthesis

11synthesis methods
-

Yield:23687-27-6 99%

Reaction Conditions:

with C20H32Cl4Cu2N4O4 in water at 60; for 1 h;Inert atmosphere;Schlenk technique;

Steps:

2.4. General procedure for the reduction of nitro compounds withcopper complex catalyst

General procedure: Copper complex (0.001 mmol, 1mol%), appropriate nitro compounds (0.1 mmol, 1.0 equiv) and NaBH4 (10.0 mmol, 10 equiv)in water (2.0 mL) were charged into a 15 mL pressure tube under air atmosphere. Subsequently, the resulting mixture was stirred atroom temperature in closed vessel. After completion of the reaction(monitored by TLC), the crude reaction mixturewas extraction with ether (3 2 mL), and analyzed by GC-MS chromatography using n-dodecaneas an internal standard.

References:

Du, Jun;Gao, Li-Li;Jia, Wei-Guo;Li, Mei;Zhi, Xue-Ting [Journal of Molecular Structure,2020,vol. 1217]

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