成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
77017-20-0

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate synthesis

2synthesis methods
2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
-

Yield:77017-20-0 100%

Reaction Conditions:

Stage #1: 21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetatewith formic acid in propan-2-one at 0; for 0.25 h;
Stage #2: with potassium permanganate in propan-2-one at -5 - 5; for 1.5 h;Temperature;

Steps:

1-3

Oxidation reaction: add 20g of tetraene acetate into the reaction flask,600mL acetone,Cool down to 0,Add 6mL formic acid,After 15 minutes of incubation reaction,Add 100 mL of 18% potassium permanganate solution to the reaction vessel,The control temperature of the dripping process does not exceed 5,The dripping is completed within 30 minutes, and the temperature is kept at 0±5 and reacted for 1 hour.After thin layer analysis to no raw material,Then add 80 mL of reducing solution (10% sodium carbonate aqueous solution) into the reactor,Stir and react for 10 minutes,The reaction system was heated to 35°C and filtered,Concentrate the filtrate until there is no acetone smell,Then add 900 mL of water to the filtrate,Cool down to below 5,Let stand for 1 hour,Suction filtration and drying to obtain 20 g of oxide (1),The yield was 100%.

References:

CN113480593,2021,A Location in patent:Paragraph 0023; 0025-0027; 0031-0033; 0037-0039

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Related Search: