2,3,4-TRI-O-ACETYL-ALPHA-L-ARABINOPYRANOSYL BROMIDE synthesis
- Product Name:2,3,4-TRI-O-ACETYL-ALPHA-L-ARABINOPYRANOSYL BROMIDE
- CAS Number:75247-31-3
- Molecular formula:C11H15BrO7
- Molecular Weight:339.14
4258-00-8
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Yield:75247-31-3 53%
Reaction Conditions:
with hydrogen bromide;acetic acid in dichloromethane at 0 - 20; for 3 h;
Steps:
General procedure for the bromination A2
General procedure: HBr (33 % wt in acetic acid) was added dropwise to a cooled solution (0 °C) of the peracetylated saccharide in dichloromethane (10 mL) and stirred for 3 h at rt. Ice water (50 mL) was added to the mixture and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The combined organic layers were washed with 0.5 % Na2S2O3 (1 x 75 mL), sat. NaHCO3 (3 x 75 mL), brine (1 x 75 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product crystallized from diethylether/pentane to afford the halogenated substrate.
References:
Bachmann, Thomas;Schnurr, Christian;Zainer, Laura;Rychlik, Michael [Carbohydrate Research,2020,vol. 489,art. no. 107940] Location in patent:supporting information