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ChemicalBook CAS DataBase List 2-BROMO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
72850-79-4

2-BROMO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
2: 72 percent / ethanol / 16 h / Heating
3: 1.) 85percentH3PO4, 70percent HNO3, aq. NaNO2, 2.) aq. HBr, CuBr; / 1.) -10 to -5 deg C, 10 min;

References:

Lee, Len F.;Schleppnik, Francis M.;Howe, Robert K. [Journal of Heterocyclic Chemistry,1985,vol. 22,p. 1621 - 1630]

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