ChemicalBook CAS DataBase List 7-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE

7-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE synthesis

7synthesis methods

Product Name:7-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
CAS Number:30384-94-2
Molecular formula:C9H8N2O
Molecular Weight:160.17

874-39-5 Synthesis

874-39-5
84 suppliers
$30.00/250mg

93-61-8
286 suppliers
$10.00/5G

7-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE

30384-94-2
46 suppliers
$45.00/10mg

Yield:30384-94-2 98.8%

Reaction Conditions:

with tert.-butylhydroperoxide;cyclopentadienyltricarbonyliron;[copper(II)(trifluoroacetylacetonate)₂];N-butylpyridine p-toluenesulfonate in ethanol at 80; for 11 h;Reagent/catalyst;

Steps:

4

To the dry reaction vessel was added an appropriate amount of organic solvent ethanol, and then 100 mmol of the compound of formula (II), 150 mmol of compound of formula (III), 5 mmol of copper trifluoroacetylacetonate, 200 mmol of TBHP and 6 mmol of reaction aid (5 mmol Butylpyridine p-toluenesulfonate and 1 mmol of cyclooctatetriene tetracarbonyl iron) was added elevated temperature to 80 ° C and reacted at that temperature for 11 hours.After completion of the reaction, the mixture was allowed to cool to room temperature, and then the saturated aqueous solution of sodium bicarbonate was sufficiently washed. The organic phase was separated, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was separated by silica gel column chromatography (column chromatography The mixture was a mixture of ethyl acetate and n-propanol, and the volume ratio of the two was 10: 2) to give the compound of formula (I) in a yield of 98.8%.

References:

CN104592225,2016,B Location in patent:Paragraph 0050- 0053

67-68-5 Synthesis