ChemicalBook CAS DataBase List 7-Aminoisoquinoline

7-Aminoisoquinoline synthesis

8synthesis methods

Product Name:7-Aminoisoquinoline
CAS Number:23707-37-1
Molecular formula:C9H8N2
Molecular Weight:144.17

13058-73-6
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23707-37-1
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$29.00/100mg

Yield: 90%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 20; for 24.5 h;

Steps:

1 Synthesis of isoquinolin-7-amine (31-4)
Synthesis of isoquinolin-7-amine (31-4)
To a suspend solution of Pd/C (10%, 100 mg) in methanol (20 mL) was added 31-3 (200 mg, 1.15 mmol) in methanol (40 mL).
After having been degassed and recharged with hydrogen, the mixture was then stirred at room temperature for 24.5 h. TLC showed that the reaction was complete.
The Pd/C was removed by filtration and the solvent was evaporated.
The residual was used without further purification (150 mg, yield 90%).

References:

Nivalis Therapeutics, Inc.;Wasley, Jan;Rosenthal, Gary J.;Sun, Xicheng;Strong, Sarah;Qiu, Jian US9138427, 2015, B2 Location in patent:Page/Page column 307

42923-79-5 Synthesis