ChemicalBook CAS DataBase List 6-Fluoro-2-oxindole

6-Fluoro-2-oxindole synthesis

8synthesis methods

Product Name:6-Fluoro-2-oxindole
CAS Number:56341-39-0
Molecular formula:C8H6FNO
Molecular Weight:151.14

39616-95-0 Synthesis

39616-95-0
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56341-39-0
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Yield:56341-39-0 91%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in acetic acid under 2585.81 Torr;

Steps:

IV 6-Fluoro-2-indolinone
With addition of 20 g of palladium on activated carbon (10%), 119 g of 4-fluoro-2-nitrophenylacetic acid (starting material III) are hydrogenated in 600 ml of acetic acid under a hydrogen pressure of 50 psi. The catalyst is filtered off with suction and the solvent is distilled off. The crude product is triturated with 500 ml of petroleum ether, filtered off with suction, washed with water and dried. [0239] Yield: 82.5 g (91% of theory) [0240] Rf value: 0.30 (silica gel, petroleum ether/ethyl acetate 1:1) [0241] C8H6FNO [0242] Mass spectrum: m/z=150 [M-H]-

References:

Boehringer Ingelheim Pharma GmbH & Co. KG US2005/43389, 2005, A1 Location in patent:Page/Page column 19

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147124-38-7 Synthesis