Diethyl 2-(4-fluoro-2-nitrophenyl)malonate synthesis
- Product Name:Diethyl 2-(4-fluoro-2-nitrophenyl)malonate
- CAS Number:147124-35-4
- Molecular formula:C11H10FNO6
- Molecular Weight:271.2
Yield:147124-35-4 98%
Reaction Conditions:
with caesium carbonate in DMF (N,N-dimethyl-formamide) at 20; for 24 h;
Steps:
The reaction of 2,5-difluoronitrobenzene (XII) with malonic acid dimethyl ester (XI) at room temperature in the system caesium carbonate/dimethylformamide also leads after 24 hours in 98% yield to the desired product XIII (scheme 3):
References:
US6774242,2004,B1 Location in patent:Page column 4
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