ChemicalBook CAS DataBase List 6-Bromopyridine-2-carboxamide 98%

6-Bromopyridine-2-carboxamide 98% synthesis

5synthesis methods

Product Name:6-Bromopyridine-2-carboxamide 98%
CAS Number:25194-52-9
Molecular formula:C6H5BrN2O
Molecular Weight:201.02

21190-87-4 Synthesis

21190-87-4
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$10.00/5g

25194-52-9
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$22.00/250mg

Yield: 100%

Reaction Conditions:

with ammonium chloride;benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine at 20;

Steps:

1 Step 1: Preparation of 6-bromopicolinamide
General procedure: Step 1: Preparation of 6-bromopicolinamide Using the same reaction conditions as described in step 6 of example 1 , 6-bromopicolinic acid (2g, 9.9 mmol) was coupled with ammonium chloride (787mg, 14.851 mmol) using EDCI.HC1 (2.8g, 14.851 mmol), HOBt (2.0g, 14.851 mmol) and DIPEA (3.8g, 29.750 mmol) in DMF (lOmL) to get the crude product. The resultant crude was purified using 60-120 silica- gel column chromatography and compound was eluted using 50% ethyl acetate in hexane as eluent to afford the title compound (2.0g, 100%). 1HNMR (CDCI₃, 300MHz): δ 8.18-8.16 (d, 1H), 7.7.63-7.5656-7.63 (m, 2H), 5.80-5.60 (bs, 2H). ⁺.

References:

AURIGENE DISCOVERY TECHNOLOGIES LIMITED;GUMMADI, Venkateshwar, Rao;SAMAJDAR, Susanta WO2015/104688, 2015, A1 Location in patent:Page/Page column 23-24