5-Methoxy-2-nitrobenzyl alcohol synthesis

5synthesis methods

Product Name:5-Methoxy-2-nitrobenzyl alcohol
CAS Number:879-55-0
Molecular formula:C8H9NO4
Molecular Weight:183.16

1882-69-5
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879-55-0
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$175.00/1g

Yield:879-55-0 97%

Reaction Conditions:

with borane-THF in tetrahydrofuran at 0;Reflux;

Steps:

7

Example 7: (5-Methox -2-nitrophenyl)methanolTo the solution of 5-methoxy-2-nitrobenzoic acid (20 g, 1.0 mol) in THF (100 mL) was added BH₃ (1.0 M in THF, 30.4 mL, 3.0 eq) at 0 ^°C. The mixture was refluxed for 3 h, diluted with water (200 mL) and extracted with DCM (100 ml * 3). The combined organic lays were dried over MgS0₄, evaporated to afford (5-methoxy-2- nitrophenyl)methanol (18 g, yield: 97%), as a white solid. 1HNMR (400 MHz, DMSO- de) δ: 8.13 (d, / = 6.4 Hz, 1H), 7.34 (d, / = 6.4 Hz, 1H), 7.02 (s, 1H), 5.60-5.58 (m, 1H), 4.84 (d, / = 8.0 Hz, 2H), 3.89 (s, 3H); ESI-MS: m z 184.1 ([M+l] ⁺).

References:

WO2012/109108,2012,A1 Location in patent:Page/Page column 39

2327-45-9 Synthesis