Yield:779345-37-8 77%

Reaction Conditions:

with sulfuric acid;dihydrogen peroxide

Steps:

429 429A-Preparation of 5-Fluoro-2-nitro-pyridine
429A-Preparation of 5-Fluoro-2-nitro-pyridine To concentrated H₂SO₄ at 0° C. was added 4 ml of 3% H₂O₂. To this solution at 0° C. was added 5-fluoro-2-amino-pyridine (250 mg, 2.23 mmol). The mixture was warmed to room temperature and stirred for 20 hr, then poured onto ice. The aqueous solution was extracted with EtOAc (3*30 ml). The combined organic layers were washed with water, brine and dried with Na₂SO₄. Removal of the solvent gave a light brown oil (245 mg, 77%). The product was used for next step without further purification.

References:

Salvati, Mark E.;Illig, Carl R.;Wilson, Kenneth Jerome;Chen, Jinsheng;Meegalla, Sanath K.;Wall, Mark James US2004/209886, 2004, A1

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