5-Bromouracil synthesis
- Product Name:5-Bromouracil
- CAS Number:51-20-7
- Molecular formula:C4H3BrN2O2
- Molecular Weight:190.98
66-22-8
791 suppliers
$5.00/10g
51-20-7
452 suppliers
$10.00/1g
Yield:51-20-7 99.9%
Reaction Conditions:
with 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione;acetic anhydride;acetic acid at 50; for 1.5 h;Temperature;Reagent/catalyst;
Steps:
1 Example 1
Uracil (100g, 892.1mmol),Solvent (glacial acetic acid (1L),Acetic anhydride (100 mL)) was mixed in a reaction flask (white suspension),Stirring reaction at 50 ° C, adding 1,3-dibromo-5,5-dimethylhydantoin(DBDMH, 153 g, 535.3 mmol), the reaction was stirred.After 1.5h,The white suspension turns into a bean curd,At this point, the TLC dot plate (sampling a little,Add THF to dilute, DCM/MeOH, 4:1),The reaction is shown to be complete.After treatment: the reaction mixture was diluted with EA,Filtering,It is dry and dry, giving a white solid.5-bromouracil(168.8 g, yield 99.9%, purity 99.3%).
References:
Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Ma Qingtong;Shan Xiaoyan;Chen Xudong;Chen Yu CN108117524, 2018, A Location in patent:Paragraph 0025; 0026; 0030; 0032; 0034; 0036; 0042; 0044
56686-16-9
254 suppliers
$5.00/1g
51-20-7
452 suppliers
$10.00/1g
