ChemicalBook CAS DataBase List 5-Bromo-2-(dimethylamino)pyridine

5-Bromo-2-(dimethylamino)pyridine synthesis

8synthesis methods

Product Name:5-Bromo-2-(dimethylamino)pyridine
CAS Number:26163-07-5
Molecular formula:C7H9BrN2
Molecular Weight:201.06

53939-30-3 Synthesis

53939-30-3
465 suppliers
$5.00/1g

506-59-2 Synthesis

506-59-2
547 suppliers
$5.00/5G

26163-07-5
106 suppliers
$6.00/1g

Yield:26163-07-5 512 mg

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 90; for 12 h;

Steps:

38.1 Step 1: Preparation of 5-bromo-N,N-lutidine-2-amine (compound 36b)

Compound 36a (650 mg, 3.38 mmol), dimethylamine hydrochloride (550.86 mg, 6.76 mmol) and potassium carbonate (1.4 g, 10.13 mmol) were added to DMF (10.0 mL) and reacted at 90°C for 12 hours.After the reaction, 200 mL of water was added, extracted with EA, the organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and separated and purified by silica gel column chromatography (DCM/MeOH=10/1) to obtain compound 36b (512 mg).

References:

WO2022/89219,2022,A1 Location in patent:Page/Page column 46

1072-97-5 Synthesis