ChemicalBook CAS DataBase List 5-(1-Methylethyl)-2-pyridinamine

5-(1-Methylethyl)-2-pyridinamine synthesis

7synthesis methods

Product Name:5-(1-Methylethyl)-2-pyridinamine
CAS Number:603310-75-4
Molecular formula:C8H12N2
Molecular Weight:136.19

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Yield: 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol under 760.051 Torr;

Steps:

39.B
Step B: Synthesis of 5-isopropylpyridin-2-amine as an intermediate; [0209] A mixture of 2-nitro-5-(prop-l-en-2-yl)pyridine (0.104 g, 0.63 mmol) and 10% palladium on carbon (0.011 g, 10% by weight) in ethanol (10 mL) was stirred under hydrogen at atmospheric pressure overnight. The reaction was filtered through diatomaceous earth and concentrated under reduced pressure to afford 5-isopropylpyridin-2-amine (0.120 g, 139%) as an oil: ¹H NMR (500 MHz, CDCl₃) δ 7.68 (d, J= 8.1 Hz, IH), 7.51 (s, IH), 7.48 (s, 2H), 7.14 (d, J= 9.1 Hz, IH), 3.45-3.42 (m, IH), 1.38 (d, J= 8.6 Hz, 6H); ESI MS m/z 137 [M+ H]⁺.

References:

The United States of America, as represented by the Secretary, Department of Health and Human Services;Science Applications International Corporation (SAIC);Albany Molecular Research, Inc. WO2009/42907, 2009, A1 Location in patent:Page/Page column 83

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