ChemicalBook CAS DataBase List (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol synthesis

8synthesis methods

Product Name:(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
CAS Number:485-19-8
Molecular formula:C19H23NO4
Molecular Weight:329.39

621-59-0 Synthesis

621-59-0
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(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol

485-19-8
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Yield:-

Steps:

Multi-step reaction with 8 steps
1: 75 percent / KOH / H₂O / 5 h / Heating
2: 93 percent / NaBH₄ / ethanol / 1.) room temperature, 18 h, 2.) reflux, 1 h
3: 96 percent / PBr₃ / tetrahydrofuran / 1.5 h / 0 °C
4: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h
5: hydrazine, acetic acid / ethanol; H₂O / 2 h / Ambient temperature
6: K₂CO₃ / acetone / 14 h / Heating
7: lithium aluminum hydride / tetrahydrofuran / Heating
8: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr