ChemicalBook CAS DataBase List 4-BENZYLOXY-3-METHOXYBENZALDEHYDE

4-BENZYLOXY-3-METHOXYBENZALDEHYDE synthesis

10synthesis methods

Product Name:4-BENZYLOXY-3-METHOXYBENZALDEHYDE
CAS Number:2426-87-1
Molecular formula:C15H14O3
Molecular Weight:242.27

100-39-0
433 suppliers
$10.00/10g

121-33-5 Synthesis

121-33-5
1125 suppliers
$9.00/1g

2426-87-1
243 suppliers
$8.00/5g

Yield:2426-87-1 100%

Reaction Conditions:

with potassium carbonate in methanol; for 4 h;Reflux;

Steps:

3-benzyloxy-4-methoxybenzaldehyde 5:

General procedure: The mixture of aldehyde 4 (10 g, 65.8 mmol), benzyl bromide (9.38 mL, 79.0 mmol), and potassium carbonate (10.9 g, 79.0 mmol) in methanol (40 mL) was refluxed for 4 h. The reaction mixture was filtered and the filtrate was evaporated under reduced pressure. Chloroform (80 mL) was added to the residue, and the solution was washed with water (2 × 30 mL), the organic layer was filtered using a Biotage ISOLUTE phase separator and then evaporated to afford a white powder (15 g, yield: 100%).

References:

Shen, Li;Sun, Dianqing [Tetrahedron Letters,2011,vol. 52,# 35,p. 4570 - 4574] Location in patent:supporting information; experimental part

100-44-7 Synthesis