ChemicalBook CAS DataBase List 4-(TRIFLUOROMETHYLTHIO)ACETOPHENONE

4-(TRIFLUOROMETHYLTHIO)ACETOPHENONE synthesis

8synthesis methods

Product Name:4-(TRIFLUOROMETHYLTHIO)ACETOPHENONE
CAS Number:713-67-7
Molecular formula:C9H7F3OS
Molecular Weight:220.21

1-{4-[(trifluoromethyl)sulfanyl]phenyl}ethan-1-ol

21101-66-6
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713-67-7
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Yield:713-67-7 95 %Chromat.

Reaction Conditions:

with potassium carbonate in n-heptane at 80; under 750.075 Torr; for 24 h;

Steps:

S4. Procedure for the synthesis of aldehydes and ketones

General procedure: A magnetic stir bar, 0.5 mmol alcohol and 3 mL n-heptane solvent were added to 20 mL glass tube. Then, 35mg catalyst and 10 mol% of K2CO3 were added. The glass tube containing reaction mixture was f itted withseptum and connected to a balloon containing one bar of air. Then the glass tube was placed into a preheatedaluminum block at 85°C. Temperature inside the reaction tube was measured to be 80 oC and this temperaturehas been taken as the reaction temperature. The reaction was allowed to progress under continuous stirringfor the required time at 80 °C. Af ter completion of the reaction, the glass tube was cooled down to roomtemperature. Afterwards, the catalyst was f iltered-off and washed with ethyl acetate. The solvent f rom thef iltrate containing the reaction products was removed in vacuum and the corresponding aldehyde/ketone waspurif ied by column chromatography. All products were analyzed by GC-MS and NMR spectroscopy analysis.In the case of yields determined the by GC, 100 μL n-hexadecane was added to the reaction vial containingthe products and diluted with ethyl acetate. Then, the reaction mixture containing catalyst and products wasf iltered through a plug of silica and the filtrate containing product was analyzed by GC.

References:

Bartling, Stephan;Beller, Matthias;Chandrashekhar, Vishwas G.;Jagadeesh, Rajenahally V.;Rabeah, Jabor;Rockstroh, Nils;Senthamarai, Thirusangumurugan [Chem,2022,vol. 8,# 2,p. 508 - 531] Location in patent:supporting information

13329-40-3 Synthesis