ChemicalBook CAS DataBase List 4-Piperidinol, 4-methyl-, hydrochloride (1:1)

4-Piperidinol, 4-methyl-, hydrochloride (1:1) synthesis

9synthesis methods

Product Name:4-Piperidinol, 4-methyl-, hydrochloride (1:1)
CAS Number:586375-35-1
Molecular formula:C6H14ClNO
Molecular Weight:151.6345

406235-30-1 Synthesis

406235-30-1
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$22.00/250mg

4-Piperidinol, 4-methyl-, hydrochloride (1:1)

586375-35-1
96 suppliers
$24.75/0.5g

Yield: 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;methanol at 0 - 20; for 4 h;

Steps:

4-Methylpiperidin-4-ol hydrochloride:
To solution of tert-butyl 4-hydroxy-4-methylpiperidine- 1 -carboxylate (5 g, 23.2 mmol) inMeOH (5 mL) was added 4.0 M HC1 in 1,4-Dioxane (17 mL) at 0 °C. The reaction mixturewas stirred at room temperature for 4 h. After completion, the volatiles were concentrated under reduced pressure to afford 3 g of 4-methylpiperidin-4-ol hydrochloride (Quantitative).

References:

THE BROAD INSTITUTE, INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;HOLSON, Edward;WAGNER, Florence, Fevrier;WEIWER, Michel;SCOLNICK, Edward;PALMER, Michelle;DORDEVIC, Luka;LEWIS, Michael;PAN, Jennifer, Q.;ZHANG, Yan-Ling;XU, Qihong WO2016/100940, 2016, A1 Location in patent:Page/Page column 161

3970-66-9 Synthesis