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ChemicalBook CAS DataBase List 4-Phenoxyphenol
831-82-3

4-Phenoxyphenol synthesis

14synthesis methods
-

Yield:831-82-3 86%

Reaction Conditions:

with methanol;copper(II) ferrite at 20; for 24 h;

Steps:

3 Synthesis of p-phenoxyphenol
In a 10 mL round bottom flask, p-benzoquinone (0.108 g, 1.0 mmol), phenylboronic acid (0.146 g, 1.2 mmol), copper ferrite (0.0120 g, 0.05 mmol), and 2 mL of methanol were added as solvents, and the reaction was carried out at room temperature for 24 hours. The solvent was removed under reduced pressure, washed with deionized water (10 mL), extracted with dichloromethane (3×10 mL),The organic phases are combined, washed with saturated sodium chloride solution, dried with anhydrous magnesium sulfate, filtered with suction, and the filtrate is spin-dried to obtain a crude product. Purified and separated by column chromatography to obtain 160.1 mg of white solid with a yield of 86%.

References:

East China University of Science and Technology;Song Gonghua;Xia Qi;Wang Jiayi;Peng Yanqing;Fu Xi CN112079693, 2020, A Location in patent:Paragraph 0046-0049

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