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ChemicalBook CAS DataBase List 4-Morpholinoaniline
2524-67-6

4-Morpholinoaniline synthesis

13synthesis methods
-

Yield:2524-67-6 99%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethanol at 20; for 3 h;

Steps:

5.1.62. 1-methyl-1H-pyrazol-4-amine (18a)
General procedure: To 17a (1 g, 7.8 mmol) in EtOH (20 mL) was added 10% Pd/C50 mg. The reaction mixture was stirred for 3 h under hydrogen at roomtemperature. The mixture was then filtered with Celite, and the filtratewas concentrated and dried under vacuum to yield 0.74 g (97%) of 18aas a white solid. MS (ESI) m/z 98 [M+H]+.

References:

Yu, Ru-Nan;Chen, Cheng-Juan;Shu, Lei;Yin, Yuan;Wang, Zhi-Jian;Zhang, Tian-Tai;Zhang, Da-Yong [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 8,p. 1646 - 1657]

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