ChemicalBook CAS DataBase List 4-Formylmorpholine

4-Formylmorpholine synthesis

12synthesis methods

Product Name:4-Formylmorpholine
CAS Number:4394-85-8
Molecular formula:C5H9NO2
Molecular Weight:115.13

110-91-8 Synthesis

110-91-8
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$9.00/1g

64-18-6 Synthesis

64-18-6
1084 suppliers
$22.12/250ML

4394-85-8
305 suppliers
$6.00/25g

Yield:4394-85-8 100%

Reaction Conditions:

with (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate;sodium hydrogencarbonate;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in water at 20; for 3 h;Reagent/catalyst;Solvent;

Steps:

General procedure for N-formylations

General procedure: To a solution of amine (1 equiv), formic acid (5 equiv), sodium bicarbonate (10 equiv), and glyceroacetonide-Oxyma 1 (2 equiv) in H₂O (0.2-0.3 M) solution was added EDCI (2 equiv) The reaction mixture was stirred for 3 h and quenched with 1% aq HCl. The aqueous phase was extracted with EtOAc (or CHCl₃ or CHCl₃-MeOH (10/1). The combined organic extracts were dried over Na₂SO₄ and evaporated in vacuo. Purification by a silica gel chromatography (or sephadex LH20) afforded the desired compound (yields were given in Table 1). Similarly, N-formylations were performed with Oxyma 1 in DMF-H₂O (9/1).

References:

Aleiwi, Bilal A.;Mitachi, Katsuhiko;Kurosu, Michio [Tetrahedron Letters,2013,vol. 54,# 16,p. 2077 - 2081]

110-91-8 Synthesis

110-91-8
691 suppliers
$9.00/1g