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ChemicalBook CAS DataBase List 4-METHYLPHENYLACETONE
2096-86-8

4-METHYLPHENYLACETONE synthesis

10synthesis methods
-

Yield:2096-86-8 83%

Reaction Conditions:

with oxone;sodium iodide in water;acetonitrile at 20; for 15 h;Green chemistry;

Steps:

catalytic oxidative 1,2-shift ofarylalkenes

General procedure: To a mixture solvent MeCN-H2O (5:1) (2 mL), α-methylstyrene (0.5 mmol), Oxone (1.0 mmol) and NaI (0.05 mmol) were added. The mixture was stirred at room temperature for 15 h, then H2O (5 mL) was added. Extraction of the mixture with CH2Cl2 (3 * 5 mL) and the combined organic layer was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified on silica gel plate (5:1 hexane-ethyl acetate) to give 1-phenylpropan-2-one in 81% of yield.

References:

Zhu, Min;Zhao, Yang [Chinese Chemical Letters,2015,vol. 26,# 2,p. 248 - 250]

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