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2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone synthesis
- Product Name:2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone
- CAS Number:106797-53-9
- Molecular formula:C12H16O4
- Molecular Weight:224.25
![1-Propanone, 1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-](/CAS/20210111/GIF/159119-01-4.gif)
159119-01-4
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106797-53-9
241 suppliers
$12.00/10g
Yield:106797-53-9 92%
Reaction Conditions:
with N-Bromosuccinimide;dimethyl sulfoxide at 60; for 24 h;Schlenk technique;
Steps:
26 Embodiment 262 - hydroxy -4 ' - (2 - hydroxy ethoxy group) -2 - methylpropiophenone preparation
Taking a 25 ml Schlenk reaction tube, adding N - bromo succimide (NBS) 18 mg (0.1mmol) as catalyst, 4' - (2 - hydroxy ethoxy group) -2 - methylpropiophenone 105 mg (0.5mmol), dimethyl sulfoxide (DMSO) 1 ml as the oxidizing agent, carbonylating and solvent, for 100 °C stirring for 24 hours. After the reaction by adding ethyl acetate 15 ml, salt water 3 ml, ethyl acetate 3 times, the combined organic phase, column chromatography separation to obtain 2 - hydroxy -4 ' - (2 - hydroxy ethoxy group) -2 - methylpropiophenone pure product 103 mg, yield 92%.
References:
CN104710256,2017,B Location in patent:Paragraph 0174-0177
![1-Propanone, 1-[4-[2-(acetyloxy)ethoxy]phenyl]-2-methyl-](/CAS/20200401/GIF/106797-52-8.gif)
106797-52-8
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106797-53-9
241 suppliers
$12.00/10g
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6192-44-5
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79-30-1
369 suppliers
$10.00/10g
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106797-53-9
241 suppliers
$12.00/10g
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622-86-6
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106797-53-9
241 suppliers
$12.00/10g
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108-95-2
744 suppliers
$14.00/25g
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106797-53-9
241 suppliers
$12.00/10g