ChemicalBook CAS DataBase List 4-CYANO-4'-NITRODIPHENYL

4-CYANO-4'-NITRODIPHENYL synthesis

13synthesis methods

Product Name:4-CYANO-4'-NITRODIPHENYL
CAS Number:31835-63-9
Molecular formula:C13H8N2O2
Molecular Weight:224.21

850623-36-8 Synthesis

POTASSIUM (4-CYANOPHENYL)TRIFLUOROBORATE

850623-36-8
71 suppliers
$7.00/250mg

586-78-7
1 suppliers
$14.00/5g

31835-63-9
34 suppliers
$45.00/10mg

Yield:31835-63-9 95%

Reaction Conditions:

with palladium diacetate;potassium carbonate in ethanol;water at 80; for 1 h;Suzuki-Miyaura Coupling;

Steps:

General procedure for the Suzuki-Miyaura reaction of aryl bromides with potassium aryltrifluoroborates

General procedure: A mixture of aryl bromides (0.5 mmol), potassium aryltrifluoroborates (0.6 mmol), K₂CO₃ (0.5 mmol), Pd(OAc)₂ (1 mol %), EtOH/H₂O (2 mL/2 mL) was stirred at 25 °C in air for the indicated time. The reaction mixture was added to brine (15 mL) and extracted with ethyl acetate (3×15 mL). The solvent was concentrated under vacuum, and the product was isolated by short-column chromatography on silica gel (200-300 mesh).

References:

Liu, Chun;Li, Xinmin;Gao, Zhanming;Wang, Xinnan;Jin, Zilin [Tetrahedron,2015,vol. 71,# 23,p. 3954 - 3959] Location in patent:supporting information