ChemicalBook CAS DataBase List 4-CUMYLPHENOL

4-CUMYLPHENOL synthesis

11synthesis methods

Product Name:4-CUMYLPHENOL
CAS Number:599-64-4
Molecular formula:C15H16O
Molecular Weight:212.29

98-83-9 Synthesis

98-83-9
300 suppliers
$10.00/25mL

108-95-2 Synthesis

108-95-2
737 suppliers
$14.00/25g

599-64-4
171 suppliers
$15.00/25g

Yield:599-64-4 80%

Reaction Conditions:

with H₂SO₄-SiO₂ in toluene at 85;Inert atmosphere;Friedel-Crafts Alkylation;

Steps:

1 Embodiment 14-isopropyl phenyl phenol preparation

The preparation method is as follows: 1) under the protection of nitrogen, the 188g (2mol) phenol, 0.94g solid acid H ₂ SO ₄-SiO ₂ and 300 ml toluene added into the reactor, heating to 85 °C, keeping temperature 85 °C, adding dropwisely to the reactor 118g (1mol) α-methyl styrene, α-methyl styrene to control dropping acceleration, applied to the drop 1 drops hours, then in the 85 °C to continue reaction 20-40 minutes, to obtain a reaction liquid. 2) filtering the reaction liquid, and removing the solid acid H ₂ SO ₄-SiO ₂, adding the filtrate extraction aqueous solution of sodium bicarbonate 200ml0.5%, takes organically phase, deionized water for extracting secondary (2 × 200 ml), takes organically , the toluene turns on lathe does , by adding 450 ml hexane and toluene mixed solution (1:1v/v), recrystallization, separating white crystalline 169.6g, the yield is 80%.

References:

CN105237359,2016,A Location in patent:Paragraph 0017; 0018; 0019; 0020; 0021; 0022; 0023

80-05-7 Synthesis