ChemicalBook CAS DataBase List 4-Carboxylphenylboronic acid pinacol ester

4-Carboxylphenylboronic acid pinacol ester synthesis

12synthesis methods

Product Name:4-Carboxylphenylboronic acid pinacol ester
CAS Number:180516-87-4
Molecular formula:C13H17BO4
Molecular Weight:248.08

76-09-5 Synthesis

76-09-5
380 suppliers
$8.19/250mg

14047-29-1
460 suppliers
$10.00/5 g

4-Carboxylphenylboronic acid pinacol ester

180516-87-4
231 suppliers
$8.00/1g

Yield:180516-87-4 93.7%

Reaction Conditions:

in hexane at 70; for 3 h;Temperature;Time;Concentration;

Steps:

1
To a 500 mL reaction flask was added p-carboxyphenylboronic acid (50 g, 0.3 mol), pinacol (39 g, 0.33 mol), n-hexane 100 g, and the temperature was raised to 70 ° C, and the reaction was carried out for 3 hours, and concentrated under reduced pressure. Drying in vacuo gave 73 g of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid as a white solid. Yield: 98%.

References:

Zhejiang Keju Bio-pharmaceutical Co., Ltd.;Yang Yong;Yang Ming;Shen Chao;Wang Dong CN109053780, 2018, A Location in patent:Paragraph 0021; 0038; 0041; 0047; 0053; 0059; 0065; 0071

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150-13-0 Synthesis