ChemicalBook CAS DataBase List 4-Bromo-2,5-dimethylbenzoic acid

4-Bromo-2,5-dimethylbenzoic acid synthesis

11synthesis methods

Product Name:4-Bromo-2,5-dimethylbenzoic acid
CAS Number:276677-03-3
Molecular formula:C9H9BrO2
Molecular Weight:229.07

110-05-4 Synthesis

110-05-4
266 suppliers
$23.00/100mL

7697-28-1
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$16.00/5G

276677-03-3
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$65.00/100mg

Yield:276677-03-3 60%

Reaction Conditions:

with potassium acetate;palladium diacetate at 80; under 760.051 Torr; for 24 h;

Steps:

13 Preparation of 4-bromo-2,5-dimethylbenzoic acid

0.6 mmol of potassium acetate, 0.3 mmol of 4-bromo-3-methylbenzoic acid,Palladium acetate 0.03 mmol, peroxydi-tert-butyl ether 0.6 mmol,0.8 mL of hexafluoroisopropanol was added to a 15 mL reaction tube and placed in an oil bath at 80 ° C.Reacting in an air atmosphere at a pressure of 1 atmosphere for 24 hours;After cooling to room temperature, the reaction solution was diluted with ethyl acetate and washed with water.The organic phase is dried over anhydrous Na2SO4.Filtered, concentrated,Purification by thin layer chromatography gave 41 mg of the desired product.White solid in 60% yield.

References:

CN109970551,2019,A Location in patent:Paragraph 0072-0075