ChemicalBook CAS DataBase List 4-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

4-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER synthesis

3synthesis methods

Product Name:4-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
CAS Number:35212-95-4
Molecular formula:C10H7ClO2S
Molecular Weight:226.68

6361-22-4 Synthesis

6361-22-4
134 suppliers
$17.00/250mg

2365-48-2 Synthesis

2365-48-2
352 suppliers
$14.00/25g

4-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER

35212-95-4
46 suppliers
$58.00/1g

Yield:35212-95-4 92%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 60;

Steps:

1 Methyl 4-chlorobenzo[b]thiophene-2-carboxylate

2-chloro-6-nitrobenzaldehyde (556.5 mg, 3.0 mmol), methyl mercaptoacetate (274 uL, 3.0 mmol), K2C03 (414 mg, 3.0 mmol) and DMF (10 mL) were added to a 50 ml round bottom flask, and stirred at 60 °C overnight. The DMF was removed in vacuo, and the crude residue was dissolved in ethyl acetate (30 ml) and water (10 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2x). The combined organics were dried (MgSO4) and concentrated to give title compound (621 mg, 92%). ‘H NMR (CDCI3, 400 MHz) ? 8.15 (d, IH, J 0.4 Hz), 7.68 (ddd, 1H, J 0.8, 1.6, 7.2 Hz), 7.357.31 (m, 2H), 3.89 (s, 3H).

References:

WO2016/191366,2016,A1 Location in patent:Page/Page column 34; 35

387-45-1 Synthesis