ChemicalBook CAS DataBase List 2,6-Dichlorobenzaldehyde

2,6-Dichlorobenzaldehyde synthesis

11synthesis methods

Product Name:2,6-Dichlorobenzaldehyde
CAS Number:83-38-5
Molecular formula:C7H4Cl2O
Molecular Weight:175.01

1194-65-6
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83-38-5
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Yield:83-38-5 97 %Chromat.

Reaction Conditions:

with lithium diisobutylmorpholinoaluminum hydride in tetrahydrofuran;hexane at 0; for 0.5 h;

Steps:

Partial Reduction of Tertiary Amides and AromaticNitriles to Aldehydes with LDBMOA.

General procedure: The following procedure for reduction of N,N-dimethylbenzamide with LDBMOA is representative. To a solution of N,N-dimethylbenzamide (0.149 g, 1.0 mmol) in THF (10.0 mL) containing naphthalene as an internal standard was added LDBMOA (2.4 mL, 0.5 M in THF-hexanes, 1.2 mmol) at 0 °C. After 30 min, the reaction mixture was hydrolyzed with 1 N aq HCl (10 mL) and extracted with diethyl ether. The combined organic layers were dried over anhydrous magnesium sulfate, and filtered. After the removal of solvents in vacuum and purification of residue by column chromatography on silica gel gave benzaldehyde (0.103 g, 97%).

References:

Kim, Yu Ri;An, Duk Keun [Bulletin of the Korean Chemical Society,2012,vol. 33,# 12,p. 4194 - 4196]

118-69-4 Synthesis