ChemicalBook CAS DataBase List 3-Pyridinamine,6-chloro-N-methyl-(9CI)

3-Pyridinamine,6-chloro-N-methyl-(9CI) synthesis

4synthesis methods

Product Name:3-Pyridinamine,6-chloro-N-methyl-(9CI)
CAS Number:120739-84-6
Molecular formula:C6H7ClN2
Molecular Weight:142.59

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Yield: 87%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 20; for 6 h;

Steps:

1.2 2. Preparation of Compound III
Compound II (52.0 g, 332 mmol) was dissolved in THF (300 ml). Lithium aluminumtetrahydride(25.2 g, 664 mmol) was added slowly in portions at room temperature. The reaction was stirred for 6 h. Sodium sulfate decahydrate was added to the reaction solution until the precipitation was complete. After filtration, the filtrate was concentrated to dryness to give compound III (41.0 g, 87%) as an oil.

References:

Yangtze River Pharmaceutical Group-Sichuan Hairong Pharmaceutical Co., Ltd;Sichuan Haihui Pharmaceutical Co., Ltd;Wang, Qiang;Cao, Kang Ping;Xie, Yi Peng;Gu, Xin;Zhou, Xin Yu;He, Xiao;Yangzijiang Pharmaceutical Group Sichuan Hairong Pharmaceutical Co., Ltd.;Sichuan Haihui Pharmaceutical Co., Ltd.;Wang Qiang;Cao Kangping;Xie Yipeng;Gu Xin;Zhou Xinyu;He Xiao CN107698500, 2018, A Location in patent:Paragraph 0047; 0050-0051