ChemicalBook CAS DataBase List 3-Oxocyclopentanecarboxylic acid

3-Oxocyclopentanecarboxylic acid synthesis

8synthesis methods

Product Name:3-Oxocyclopentanecarboxylic acid
CAS Number:98-78-2
Molecular formula:C6H8O3
Molecular Weight:128.13

5400-79-3 Synthesis

5400-79-3
132 suppliers
$30.00/1g

98-78-2
237 suppliers
$10.00/250mg

Yield:98-78-2 30%

Reaction Conditions:

with sodium hydroxide in ethanol at 20; for 3 h;

Steps:

12 Example 12: Preparation of 3-oxocyclopentane-1-carboxylic acid (49)
Place 3-oxocyclopentane-1-carboxylic acid ethyl ester (1.5g, 9.6mmol, 1eq), NaOH (387mg, 9.6mmol, 21eq) and EtOH (30mL) in a 100ml round bottom single-necked flask, at Stir at room temperature for 3h.TLC monitors the completion of the reaction and removes the solvent under reduced pressureWater (20 mL) was added and extracted with ethyl acetate (1×20 mL).Adjust the aqueous phase to pH=34 with 1M dilute hydrochloric acid,The aqueous phase was then extracted with ethyl acetate (3×30 mL),Combine the organic phases, dry over anhydrous sodium sulfate, filter,The filtrate was concentrated under reduced pressure to obtain the title compound 0.5g, yield: 30%.

References:

Chinese Academy Of Medical Sciences Basis Medical Institute;Zhu Dahai;Zhang Yong;Li Changyin;Han Wanhong;Li Hu;Huang Yan CN111253246, 2020, A Location in patent:Paragraph 0433-0437

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