ChemicalBook CAS DataBase List 2-CYCLOPENTANONE CARBOXYLATE

2-CYCLOPENTANONE CARBOXYLATE synthesis

7synthesis methods

Product Name:2-CYCLOPENTANONE CARBOXYLATE
CAS Number:50882-16-1
Molecular formula:C6H8O3
Molecular Weight:128.13

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Yield:-

Reaction Conditions:

in N,N-dimethyl-formamide at 130; for 6 h;

Steps:

2 4.2.1.1. General procedure 1: synthesis of linear anilides 21a-f.
General procedure: The cyclic ketone (1 equiv) was added to a solution of magnesium methyl carbonate (2 M in DMF, 8 equiv). The reaction mixture was stirred at 130 °C for 6 h. After cooling to rt, 10% HCl solution was added until the pH became acidic. The aqueous phase was extracted with Et₂O, and the combined organic layers washed with H₂O and sat. brine, dried over MgSO₄, filtered, and concentrated in vacuo to give the carboxylic acid.

References:

Hurst, Timothy E.;Gorman, Ryan;Drouhin, Pauline;Taylor, Richard J.K. [Tetrahedron,2018,vol. 74,# 45,p. 6485 - 6496]