3-Hydroxy-4-nitrobenzoic acid synthesis
- Product Name:3-Hydroxy-4-nitrobenzoic acid
- CAS Number:619-14-7
- Molecular formula:C7H5NO5
- Molecular Weight:183.12
99-06-9
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619-14-7
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$10.00/5g
Yield:619-14-7 27%
Reaction Conditions:
with ammonium cerium (IV) nitrate in acetonitrile at 20;
Steps:
4 Preparation of 3-hydroxy-4-nitrobenzoic acid (Compound 4A)
3-hydroxybenzoic acid (220mg, 1.6mmol) was dissolved in acetonitrile and, after complete dissolution was slowly added portionwise ammonium cerium nitrate (1.26g, 2.3mmol), stirred at room temperature overnight.At the end of the reaction, the reaction was quenched with water, extracted with ethyl acetate and combined organics.Dry, concentrated under reduced pressure, and purified by column chromatographySolid product compound 4A (85 mg, 27% yield).
References:
Jiangsu Xiansheng Pharmaceutical Co., Ltd.;Chen Huanming;Liang Bo;Cao Wenjie;Zhang Guiping;Zhao Zhongqiang;Jiang Zhaojian;Zuo Gaolei;Xu Wanmei;Gong Hongju;Zhang Peng;Wang Jianghuai;Li Qingsong;Gao Chunhua CN104045552, 2019, B Location in patent:Paragraph 0114; 0115; 0116; 0117
700-38-9
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619-14-7
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55894-52-5
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124-07-2
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619-14-7
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99-06-9
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$5.00/25g
610-37-7
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619-14-7
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$10.00/5g
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