METHYL 5-NITROSALICYLATE synthesis
- Product Name:METHYL 5-NITROSALICYLATE
- CAS Number:17302-46-4
- Molecular formula:C8H7NO5
- Molecular Weight:197.14
96-97-9
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17302-46-4
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Yield: 77%
Reaction Conditions:
with potassium carbonate
Steps:
7.3.462 7.3.462 N2,N4-Bis(4-methoxy-3-methoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine (R945066)
In a manner analogous to the preparation of N2,N4-bis(3-methoxy-4-methoxycarbonyl)phenyl)-5-fluoro-2,4-pyrimidinediamine, 2-hydroxy-5-nitrobenzoic acid (1 g, 5.5 mmol), potassium carbonate (3 g, 22 mmol) and iodomethane (1 mL, 16 mmol) gave methyl 2-hydroxy-5-nitrobenzoate (880 mg, 77%).
References:
RIGEL PHARMACEUTICALS, INC.;Singh, Rajinder;Argade, Ankush;Payan, Donald;Molineaux, Susan;Holland, Sacha;Clough, Jeffrey;Keim, Holger;Bhamidipati, Somasekhar;Sylvain, Catherine;Li, Hui;Rossi, Alexander US2015/266828, 2015, A1 Location in patent:Paragraph 1025
119-36-8
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17302-46-4
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67-56-1
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$7.29/5ml-f
96-97-9
365 suppliers
$14.14/1gm:
17302-46-4
155 suppliers
$6.00/1g
96-97-9
365 suppliers
$14.14/1gm:
17302-46-4
155 suppliers
$6.00/1g
618-95-1
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$14.00/5g
17302-46-4
155 suppliers
$6.00/1g