ChemicalBook CAS DataBase List 3-Hydroxy-1-phenyl-1,2,4-triazole

3-Hydroxy-1-phenyl-1,2,4-triazole synthesis

5synthesis methods

Product Name:3-Hydroxy-1-phenyl-1,2,4-triazole
CAS Number:4231-68-9
Molecular formula:C8H7N3O
Molecular Weight:161.16

3-Hydroxy-1-phenyl-1,2,4-triazole was prepared by reacting Phenylhydrazine, urea and formic acid through condensation and cyclization reactions.

100-63-0 Synthesis

100-63-0
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4231-68-9
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Yield:-

Reaction Conditions:

with formic acid;sulfuric acid;urea in 5,5-dimethyl-1,3-cyclohexadiene

Steps:

35 1-Phenyl-3-hydroxy-1,2,4-triazole
EXAMPLE 35 (Single-pot process) 1-Phenyl-3-hydroxy-1,2,4-triazole 108 g (1 mol) of phenyl hydrazine and 60 g (1 mol) of urea were suspended in 500 ml of xylene and 111 g (1 mol) of concentrated sulfuric acid were added while stirring vigorously. The mixture was heated for 2.5 hours at 135° C. and water formed was separated via a water separator. After cooling to 90° C. 135.2 g (2.5 mols) of 85% formic acid and 25 g (0.25 mol) of concentrated sulfuric acid were added successively and the mixture was further heated for 6 hours at 95° C. After cooling, the product was filtered off, washed thoroughly with water until free from acid and dried in vacuo at 100° C. There were obtained 124.6 g (77.5% of the theory) of 1-phenyl-3-hydroxy-1,2,4-triazole having a melting point of 281°-282° C.

References:

Hoechst Aktiengesellschaft US4467098, 1984, A

64-18-6 Synthesis