ChemicalBook CAS DataBase List 3-Chloro-2-fluoro-pyridine

3-Chloro-2-fluoro-pyridine synthesis

4synthesis methods

Product Name:3-Chloro-2-fluoro-pyridine
CAS Number:1480-64-4
Molecular formula:C5H3ClFN
Molecular Weight:131.54

2402-77-9 Synthesis

2402-77-9
661 suppliers
$5.00/5g

1480-64-4
188 suppliers
$15.00/1g

Yield:1480-64-4 71.9%

Reaction Conditions:

with caesium fluoride in (methylsulfinyl)methane at 110; for 20 h;

Steps:

3-Chloro-2-fluoropyridine(2B')

General procedure: To a solution of 2,3-dichloropyridine(1.00 g, 6.76 mmol) in DMSO (33.8 ml) was added CsF (2.053 g, 13.51mmol) at room temperature. The mixture was stirred at 110 °C under air for 20h. The mixture was quenched with water at room temperature and extracted withEtOAc. The organic layer was separated, washed with water and brine, dried overNa₂SO₄ and concentrated in vacuo. The residue waspurified by column chromatography (silica gel, eluted with EtOAc in hexane) togive 3-chloro-2-fluoropyridine (0.639 g, 4.86 mmol, 71.9 %) as colorlessoil. Thecompound 3B'-8B' were prepared in amanner similar to that described for 2B'.

References:

Katoh, Taisuke;Tomata, Yoshihide;Tsukamoto, Tetsuya;Nakada, Yoshihisa [Tetrahedron Letters,2015,vol. 56,# 44,p. 6043 - 6046] Location in patent:supporting information

372-48-5 Synthesis