ChemicalBook CAS DataBase List 3-Bromo-2-fluoropyridine

3-Bromo-2-fluoropyridine synthesis

8synthesis methods

Product Name:3-Bromo-2-fluoropyridine
CAS Number:36178-05-9
Molecular formula:C5H3BrFN
Molecular Weight:175.99

52200-48-3
360 suppliers
$11.00/1g

36178-05-9
230 suppliers
$15.00/5g

Yield:36178-05-9 73%

Reaction Conditions:

with cesium fluoride in dimethyl sulfoxide at 130; for 4 h;

Steps:

3-Bromo-2-fluoropyridine(3B')
General procedure: To a solution of 2,3-dichloropyridine(1.00 g, 6.76 mmol) in DMSO (33.8 ml) was added CsF (2.053 g, 13.51mmol) at room temperature. The mixture was stirred at 110 °C under air for 20h. The mixture was quenched with water at room temperature and extracted withEtOAc. The organic layer was separated, washed with water and brine, dried overNa₂SO₄ and concentrated in vacuo. The residue waspurified by column chromatography (silica gel, eluted with EtOAc in hexane) togive 3-chloro-2-fluoropyridine (0.639 g, 4.86 mmol, 71.9 %) as colorlessoil. Thecompound 3B'-8B' were prepared in amanner similar to that described for 2B'.

References:

Katoh, Taisuke;Tomata, Yoshihide;Tsukamoto, Tetsuya;Nakada, Yoshihisa [Tetrahedron Letters,2015,vol. 56,# 44,p. 6043 - 6046] Location in patent:supporting information

FullText

372-48-5 Synthesis