ChemicalBook CAS DataBase List 3,5-Dihydroxybenzaldehyde

3,5-Dihydroxybenzaldehyde synthesis

13synthesis methods

Product Name:3,5-Dihydroxybenzaldehyde
CAS Number:26153-38-8
Molecular formula:C7H6O3
Molecular Weight:138.12

29654-55-5 Synthesis

29654-55-5
293 suppliers
$10.00/1g

26153-38-8
259 suppliers
$20.00/250mg

Yield:26153-38-8 80%

Reaction Conditions:

with chromium(VI) oxide;sulfuric acid in tetrahydrofuran at 0; for 2.5 h;

Steps:

1.2

Step 2, adding concentrated sulfuric acid (1.5 kg) to a solution of saturated chromium trioxide (770 g) to prepare a Jones reagent;The intermediate B (770 g) in tetrahydrofuran (1 kg) was cooled to 0 ° C.Adding the prepared Jones reagent to it,Adding time 0.5 hours,Stirring at 0 ° C for 2 hours;After the reaction was completed, a saturated sodium hydrogencarbonate solution (3 kg) was added dropwise thereto at 0 ° C until no bubbles were formed.Ethyl acetate (2 kg) was further added thereto, stirred for 0.5 hour, and filtered to obtain a filtrate;The filtrate was extracted three times with deionized water (1 kg each time) and the aqueous phase was extracted once more with ethyl acetate (2 kg).Combine the organic phases with a rotary evaporator,Drying at 45 ° C to give a brown solid C ( 610 g).Yield 80%

References:

CN110256214,2019,A Location in patent:Paragraph 0030-0034; 0038