ChemicalBook CAS DataBase List 3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone

3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone synthesis

3synthesis methods

Product Name:3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone
CAS Number:120004-79-7
Molecular formula:C13H16ClNO2
Molecular Weight:253.72

6940-78-9 Synthesis

6940-78-9
354 suppliers
$5.00/10g

22246-18-0 Synthesis

22246-18-0
622 suppliers
$5.00/5g

3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone

120004-79-7
160 suppliers
$60.00/2 mg

Yield: 95%

Reaction Conditions:

with lithium hydroxide in water;N,N-dimethyl-formamide at 40 - 50; for 3 h;Sealed tube;Large scale;Reagent/catalyst;Solvent;

Steps:

1-2 Example 2 Preparation of 7-(4-chlorobutoxy)-3,4-dihydroquinoline-2(1H)-ketones
Add 1.0kg of 3,4-dihydro-7-hydroxy-2(1H)-quinolinone, 3.15kg of 1-bromo-4-chlorobutane, 3.0L of DMF, 500ml of water, and 270 of lithium hydroxide into a 30L three-necked flask g.After the addition, the temperature was raised to 4050, and the reaction was sealed and kept for 3 hours. After the reaction was completed, water was added to crystallize, filtered with suction, washed twice with water, and the filter cake was dried under reduced pressure to obtain 7-(4-chlorobutoxy)-3, 4-Dihydroquinoline-2(1H)-Ketone dry product 1.48kg, yield 95.0%, purity greater than 98.5%

References:

CN104844585, 2021, B Location in patent:Paragraph 0027-0030

22246-18-0 Synthesis

22246-18-0
622 suppliers
$5.00/5g

110-56-5 Synthesis