ChemicalBook CAS DataBase List 3-(3-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

3-(3-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER synthesis

11synthesis methods

Product Name:3-(3-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
CAS Number:21575-91-7
Molecular formula:C11H11BrO3
Molecular Weight:271.11

1711-09-7 Synthesis

1711-09-7
200 suppliers
$9.00/5g

6148-64-7 Synthesis

6148-64-7
391 suppliers
$5.00/10g

3-(3-BROMO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

21575-91-7
88 suppliers
$21.00/250mg

Yield: 99%

Reaction Conditions:

with magnesium chloride;triethylamine in acetonitrile

Steps:

2.l 3-(3-Bromophenyl)-3-oxopropanoic Acid Ethyl Ester
Example 2 Part A 3-(3-Bromophenyl)-3-oxopropanoic Acid Ethyl Ester To potassium ethyl malonate (3.25 g, 19.13 mmol) in acetonitrile (50 mL) was sequentially added triethyl amine (4.1 mL, 29.16 mmol) and magnesium chloride (2.16 g, 22.78 mmol) at room temperature. After stirring the reaction mixture at room temperature for 2 hours, 3-bromobenzoyl chloride (2.0 g, 9.11 mmol) was added and the mixture was heated at 60° C. for 18 hours, concentrated under reduced pressure and partitioned between ethyl acetate (100 mL) and 1N HCl (25 mL). The ethyl acetate layer was dried over sodium sulfate and concentrated under reduced pressure to yield the title compound (2.45 g, 99%). ¹H NMR (CDCl₃): δ 8.1 (s, 1H), 7.85 (d, 1H), 7.7 (d, 1H), 7.35 (t, 1H), 4.3 (m, 2H), 3.4 (s, 1H), 1.3 (m, 3H).

References:

Iwanowicz, Edwin J.;Watterson, Scott H.;Dhar, T.G. Murali;Pitts, William J.;Gu, Henry H. US2002/40022, 2002, A1

24398-88-7 Synthesis