3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER synthesis
- Product Name:3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER
- CAS Number:212322-56-0
- Molecular formula:C18H22N4O3
- Molecular Weight:342.4
![ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE](/CAS/GIF/429659-01-8.gif)
429659-01-8
184 suppliers
$12.00/5g
212322-56-0
526 suppliers
$14.00/1 / G
Yield:212322-56-0 96%
Reaction Conditions:
with Raney nickel in tetrahydrofuran at 60;Inert atmosphere;
Steps:
3.d Example 3
(D) Preparation of intermediate VI: In a hydrogenation reaction flask,43 g of ethyl 3- (4- (methylamino) -3-nitro-N- (pyridin-2-yl) benzamido) propanoateAnd 4.7 g of Raney nickel in 500 mL of tetrahydrofuran,Nitrogen replacement 3 times, and then into the hydrogen, stirring, heating to 60 ° C reaction,TLC monitoring reaction; the reaction was completed, suction filtration, washing the filter cake with a small amount of tetrahydrofuran; the filter cake was recovered and applied; the filtrate was dried over anhydrous sodium sulfate, filtered with suction and concentrated to dryness under reduced pressure to give 38.3g Intermediate VI (6), yield 96%
References:
Nantong Changyou Pharmaceutical Technology Co., Ltd.;Li Zebiao;Yan Jun;Lin Yanfeng;Zou Lin;Zhao Yongxing CN104031031, 2017, B Location in patent:Paragraph 0028; 0033; 0035; 0040; 0042; 0047
41263-74-5
312 suppliers
$9.00/5g
212322-56-0
526 suppliers
$14.00/1 / G
82357-48-0
39 suppliers
inquiry
212322-56-0
526 suppliers
$14.00/1 / G
96-99-1
493 suppliers
$5.00/5g
212322-56-0
526 suppliers
$14.00/1 / G
103041-38-9
371 suppliers
$6.00/1g
212322-56-0
526 suppliers
$14.00/1 / G