ChemicalBook CAS DataBase List 2-Hydroxyisobutyric acid

2-Hydroxyisobutyric acid synthesis

11synthesis methods

Product Name:2-Hydroxyisobutyric acid
CAS Number:594-61-6
Molecular formula:C4H8O3
Molecular Weight:104.1

498-24-8
103 suppliers
$80.20/10g

79-41-4 Synthesis

79-41-4
496 suppliers
$14.00/5g

498-23-7
147 suppliers
$29.82/10g

594-61-6
321 suppliers
$5.00/5g

97-65-4 Synthesis

97-65-4
541 suppliers
$5.00/25g

Yield:79-41-4 51.67 %Spectr. ，498-23-7 14.7 %Spectr. ，97-65-4 5.46 %Spectr. ，594-61-6 12.62 %Spectr.

Reaction Conditions:

with sodium hydroxide in water at 190; under 112511 Torr; for 0.241667 h;Temperature;

Steps:

40

The feed solution for the experiment was prepared by mixing together a di-carboxylic acid (either itaconic, citraconic or mesaconic acid) (65 g, 0.5 moles) and sodium hydroxide (20 g, 0.5 moles) . The two solids were then dissolved in 915 g de-ionised water to give a total feed solution weight of 1 kg. The reaction solution was then fed into the ThalesNano X- Cube Flash apparatus at the required flow rate to obtain 120, 240, 366, 480, 600 and 870 seconds residence times. Every experiment was carried out at a set pressure of 150 bar (2176 psi) . The temperature of the reactor was adjusted according to the requirements of each experiment. X-Cube Flash Operation Ensure both pump lines are attached and immersed in solvent. Set the reaction pressure to the required pressure (150 bar) . Set the reaction temperature to the required temperature. Ensure that the feed line for pump 1 is inserted into the reactant feed solution bottle. Select pump 1 and set to the required flow rate of the feed solution to achieve the desired residence time of the solution in the reactor. Start the experiment and run the pumplfor 20 minutes. After running the pump for 20 minutes start to collect the liquid sample exiting the X-cube. After sufficient reactor exit has been collected, the X- Cube will need to be flushed with water to avoid cross contamination between experimental samples. Ensure that the feed line for pump 2 is inserted into the water feed bottle. Switch the liquid feed to the reactor from that fed from pump 1 (reactant solution) to that fed from pump 2 (water) . Run the pump for 20 minutes so that no reactant solution is left in the reactor. Analysis

References:

WO2013/160703,2013,A1 Location in patent:Page/Page column 26

882-09-7 Synthesis