2-(4-Chlorophenoxy)-2-methylpropionic acid synthesis
- Product Name:2-(4-Chlorophenoxy)-2-methylpropionic acid
- CAS Number:882-09-7
- Molecular formula:C10H11ClO3
- Molecular Weight:214.65
637-07-0
229 suppliers
$13.00/500mg
882-09-7
306 suppliers
$5.00/5g
Yield:882-09-7 94%
Reaction Conditions:
with methanol;sodium hydroxide in dichloromethane;water
Steps:
16
Take compound III-2 (1.8g) in a mixed solution of dichloromethane (10mL) and methanol (1mL).10% NaOH aqueous solution (10 mL) was added,The reaction was refluxed for 12 hours.The solvent was distilled off under reduced pressure,Ethyl acetate (10 mL) was added,Adjust pH to acidic with 1N HCl,Ethyl acetate (10 mL x 3) extraction,The organic phase was washed with a saturated saline solution (10 mL x 3),Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,Compound III-3 was obtained (white solid, 1.5 g, yield 94%).
References:
China Pharmaceutical University;Sun Hongbin;Yan Dingfei;Feng Zhiqi;Zhang Jia;Yao Zhiying;Zhao Wenfeng;Zhang Xiangying;Sun Geng;Han Lishuai;Wu Wenzhen;Liu Shengjie;Zhao Xing;Li Minglei;Yu Shengqi;Chen Hui;Cheng Yalong;Wang Pengfei;Dai Liang;Wen Xiaoan;Liu Jun CN110372638, 2019, A Location in patent:Paragraph 0147; 0149; 0151
67-66-3
6 suppliers
$33.60/500ml
106-48-9
476 suppliers
$10.00/5 g
67-64-1
6 suppliers
$17.30/10ml
882-09-7
306 suppliers
$5.00/5g
31637-97-5
121 suppliers
$25.00/5mg
59-67-6
1110 suppliers
$7.00/25g
882-09-7
306 suppliers
$5.00/5g
107-21-1
1327 suppliers
$10.00/25g
