ChemicalBook CAS DataBase List 2-Chloropyridine-4-carbonyl chloride

2-Chloropyridine-4-carbonyl chloride synthesis

7synthesis methods

Product Name:2-Chloropyridine-4-carbonyl chloride
CAS Number:65287-34-5
Molecular formula:C6H3Cl2NO
Molecular Weight:176

6313-54-8 Synthesis

6313-54-8
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65287-34-5
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Yield: 100%

Reaction Conditions:

with thionyl chloride at 80; for 3 h;

Steps:

xxix.a 2-Chloroisonicotinoyl chloride 172
A solution of 2-chloroisonicotinic acid (2.0 g, 12.69 mmol) in thionyl chloride (15 mL) was heated at 80 °C for 3 hours. The mixture was concentrated in vacuo and the residue resuspended in DCM (3 x 10 mL) and concentrated to remove the excess thionyl chloride to give the title compound as yellow oil (2.2 g, 100%). LCMS-C: (MeOH quench) RT 1 .79 min; m/z 172.1 [M+H]⁺

References:

CTXT PTY LTD;BERGMAN, Ylva Elisabet;FOITZIK, Richard Charles;MORROW, Benjamin Joseph;CAMERINO, Michelle Ang;WALKER, Scott Raymond;LAGIAKOS, H. Rachel;FEUTRILL, John;STEVENSON, Graeme Irvine;STUPPLE, Paul Anthony WO2016/34673, 2016, A1 Location in patent:Page/Page column 102

6313-54-8 Synthesis

6313-54-8
419 suppliers
$8.00/5g