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ChemicalBook CAS DataBase List 2-Butanone oxime
96-29-7

2-Butanone oxime synthesis

11synthesis methods
2-Butanone oxime is obtained by the reaction of butanone and hydroxylamine hydrochloride. It can also be synthesized by the reaction between butanone and hydroxylamine sulfate.
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Yield:96-29-7 99.8%

Reaction Conditions:

with ammonium sulfate;dihydrogen peroxide;sodium carbonate in water at 60; for 5 h;Reagent/catalyst;Concentration;Time;

Steps:

5 Example 5:

To the flask was added 36 g of methyl ethyl ketone (0.5 mol),535 g of a 5% ammonium chloride solution in water (0.5 mol),2% of the catalyst TS-1, turn on the stirrer, adjusted to a suitable stirring rate.The temperature gradually rose to 60 °C,At the same time, 145.75 g of a 20% aqueous solution of sodium carbonate (0.275 mol) was added dropwiseAnd 27.4% of hydrogen peroxide 65.4g (0.525mol),The time of addition was 3h; after the addition was complete, the reaction was continued for 2h. After the reaction was completed, it was cooled to room temperature.The catalyst was filtered off and analyzed by gas chromatographyButanone oxime 43.4g,The yield was 99.7%.
The procedure and operating conditions for the synthesis of butanone oxime are the same as in Example 1.The difference is that strong bases differ from ammonium salts. The yield of butanone oxime was determined by gas phase analysis in Table 1.

References:

CN106892836,2017,A Location in patent:Paragraph 0030; 0031; 0034; 0035; 0036-0041; 0044; 0045

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