ChemicalBook CAS DataBase List 2-Bromo-5-fluorobenzyl alcohol

2-Bromo-5-fluorobenzyl alcohol synthesis

6synthesis methods

Product Name:2-Bromo-5-fluorobenzyl alcohol
CAS Number:202865-66-5
Molecular formula:C7H6BrFO
Molecular Weight:205.02

94569-84-3 Synthesis

94569-84-3
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$16.00/5g

202865-66-5
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$6.00/1g

Yield:202865-66-5 99.8%

Reaction Conditions:

with sodium tetrahydroborate in ethanol;water at 0 - 20; for 1 h;

Steps:

To a solution of compound A2-1 (75.0 g, 369 mmol) in EtOH (375 rnL) was added a solution OfNaBH₄ (4.47 g, 118 mmol) in water (9 mL) at 0°C, and the mixture was stirred at rt for 1 h. The mixture was treated with water and EtOAc, and extracted with EtOAc. The extract was washed with brine, dried over Na₂SO₄. The solvent was concentrated in vacuo to give 75.6 g of compound A2-2 (yield = 99.8 %) as a colorless solid. ¹H NMR (CDCl₃) δ 7.5O-7.46(1H, m), 7.29-7.25(1H, m), 6.92-6.85(1H, m), 4.72(2H, s).

References:

WO2007/19098,2007,A2 Location in patent:Page/Page column 44

133188-66-6 Synthesis