ChemicalBook CAS DataBase List 2-Amino-5-bromo-3-nitropyridine

2-Amino-5-bromo-3-nitropyridine synthesis

8synthesis methods

Product Name:2-Amino-5-bromo-3-nitropyridine
CAS Number:6945-68-2
Molecular formula:C5H4BrN3O2
Molecular Weight:218.01

1072-97-5 Synthesis

1072-97-5
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$9.00/1g

6945-68-2
397 suppliers
$9.00/5g

Yield:6945-68-2 71%

Reaction Conditions:

with sulfuric acid;nitric acid at 0 - 20;Inert atmosphere;

Steps:

4.2. General procedure for nitration of 2-aminopyridines 7
General procedure: 2-Aminopyridine 7 (0.020 mol) was added to ice-cold concentrated sulfuric acid and the resulting solution was treated with concentrated nitric acid (1.09 mL, 0.024 mol), which was added slowly so as to maintain the reaction temperature in 0-5 °C range.The resulting solution was stirred at 0-5 °C for 1 h, warmed up to rt and stirred at that temperature overnight. It was then poured over ice and the pH was adjusted to 7-8 with 10% aq NaOH solution. The resulting precipitate was collected by filtration, washed with water and dried at 60 °C overnight to provide analytically pure 2-amino-3-nitropyridines.

References:

Sapegin, Alexander V.;Kalinin, Stanislav A.;Smirnov, Alexey V.;Dorogov, Mikhail V.;Krasavin, Mikhail [Tetrahedron,2014,vol. 70,# 5,p. 1077 - 1083]

FullText

4214-75-9 Synthesis