ChemicalBook CAS DataBase List 2-Amino-4-methylbenzoic acid

2-Amino-4-methylbenzoic acid synthesis

10synthesis methods

Product Name:2-Amino-4-methylbenzoic acid
CAS Number:2305-36-4
Molecular formula:C8H9NO2
Molecular Weight:151.16

7697-27-0 Synthesis

7697-27-0
209 suppliers
$6.00/1g

2305-36-4
196 suppliers
$6.00/1g

Yield:2305-36-4 87%

Reaction Conditions:

with ammonium hydroxide;L-2-O-methyl-chiro-inositol;copper(II) acetate monohydrate in 1-methyl-pyrrolidin-2-one at 110; for 12 h;

Steps:

Synthesis of 5a–z, 5aa; General Procedure C
General procedure: To a sealed reaction vessel were added ammonia (aq, 25percent) (1.8 mL, 12.8 mmol),Cu(OAc)2·H2O (0.13 mmol), QCT (0.26 mmol) in NMP (1.8 mL) and aryl halides(1.28 mmol). The resulting mixture was heated in an oil bath with appropriatetemperature under rapid stirring for the indicated time. After complete consumption ofthe aryl halide as monitored by TLC, the reaction vessel was cooled to r.t. It was openedto air, and the reaction mixture was extracted with ethyl acetate (3×10 mL), and theorganic layer was washed with water (2×10 mL) and once with brine (10 mL), driedwith magnesium sulfate and concentrated in vacuo. The product was purified bycolumn chromatography on silica gel.

References:

Chen, Guoliang;Chen, Yuanguang;Du, Fangyu;Fu, Yang;Wu, Ying;Zhou, Qifan [Synlett,2019,vol. 30,# 19,p. 2161 - 2168] Location in patent:supporting information

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27329-27-7 Synthesis