ChemicalBook CAS DataBase List 2-Amino-4'-bromo-1,1'-biphenyl

2-Amino-4'-bromo-1,1'-biphenyl synthesis

7synthesis methods

Product Name:2-Amino-4'-bromo-1,1'-biphenyl
CAS Number:62532-98-3
Molecular formula:C12H10BrN
Molecular Weight:248.12

589-87-7 Synthesis

589-87-7
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191171-55-8
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62532-98-3
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Yield:62532-98-3 72%

Reaction Conditions:

with tetrakis(triphenylphosphine) palladium⁽⁰⁾;potassium carbonate in ethanol;water;toluene;Reflux;

Steps:

Preparation of core 1-1

In a 3L round flask 1-Bromo-4-iodobenzene 180g (636.26mmol, 2eq) And 2-aminophenylpinacolborane (319.50 mmol, 1 eq), 18.4 g (15.97 mmol, 0.05 eq) of Pd (pph 3) 4, 132 g (998.48 mmol, 3 eq) of K 2 CO 3 , 1,500 ml / 300 ml / 300 ml of toluene / ethanol (EtOH) / H 2 O were added, and the mixture was stirred under reflux. After completion of the reaction, the reaction mixture was extracted with CH 2 Cl 2 (MC) / H 2 O and the CH 2 Cl 2 layer (MC layer) was dried with MgSO 4. The silica-gel column was purified to obtain 1-157 g of a core in 72% yield.

References:

KR2019/64508,2019,A Location in patent:Paragraph 0155-0158